Gold-catalyzed three-component spirocyclization: a one-pot approach to functionalized pyrazolidines
نویسندگان
چکیده
منابع مشابه
Gold-catalyzed three-component spirocyclization: a one-pot approach to functionalized pyrazolidines.
An efficient, highly atom economic synthesis of hitherto unknown spirocyclic pyrazolidines in a one-pot process was developed. The gold-catalyzed three-component coupling of alkynols, hydrazines and aldehydes or ketones likely proceeds via cycloisomerization of the alkynol to an exocyclic enol ether and subsequent [3 + 2]-cycloaddition of an azomethine ylide. A library of 29 derivatives with a ...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2016
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c5ob02453f